Prostate-Specific Antigen (PSA) Test. PSA is a blood test that is ordered by a physician to test a man for the presence of a protein produced by the prostate gland. The higher the PSA level, the more prone a man is to having prostate cancer. Most men will have this test recommended when they reach age 50. Some men may also develop prostate issues at an earlier age, especially if there is a family history of prostate cancer. Most insurance companies will pay for this test if ordered by a physician or if you are covered by Medicare or Medicaid.